ARMADiLLO

ARMADiLLO Precomputed BNAb Results Human V Alleles Information Help

Precomputed Results

Epitope	Type	BnAb	Breadth^a	Potency^b	VH Gene	VL Gene	CDRH3 Length	CDRL3 Length	VH Mutation Frequency	VL Mutation Frequency	Improbable Mutations (Heavy)	Improbable Mutations (Light)
CD4 Binding Site	CD4 mimicking VH1-2 derived	N49P7	100%	0.100	VH1-2	VL2-11	19	5	24.5%	14.1%	13	9
		N6	99%	0.062	VH1-2	VK1-33	13	5	30.2%	22.4%	12	6
		12A12	93%	0.221	VH1-2	VK1-33	13	5	21.9%	15.5%	14	5
		VRC01	91%	0.377	VH1-2	VK3-20	12	5	31.6%	17.2%	11	9
		3BNC117	89%	0.116	VH1-2	VK1-33	10	5	23.7%	14.8%	9	6
		VRC-CH31	84%	0.321	VH1-2	VK1-33	13	5	20.2%	15.2%	8	3
		PCIN63-71I1	84%	0.460	VH1-2	VK1-6	13	5	14.6%	12.5%	9	8
		VRC-PG04	81%	0.317	VH1-2	VK3-20	14	5	28.6%	15.2%	10	11
		VRC-PG20	80%	0.226	VH1-2	VL2-14	13	5	24.0%	14.8%	11	5
	CD4 mimicking VH1-46 derived	1-18	97%	0.048	VH1-46	VK3-20	16	9	26.4%	20.2%	8	7
		CH235.12	89%	0.700	VH1-46	VK3-15	13	8	25.0%	14.8%	16	6
		1B2530	72%	3.617	VH1-46	VL1-47	16	11	27.8%	15.7%	9	3
		8ANC131	71%	1.781	VH1-46	VK3-20	16	9	25.7%	17.2%	10	4
	Other	CH103	67%	2.281	VH4-59	VL3-1	13	10	16.9%	11.1%	2	6
V3 Glycan		PGT128	68%	0.064	VH4-39	VL2-8	19	10	19.1%	7.0%	5	2
		PGT121	66%	0.072	VH4-59	VL3-21	24	12	19.6%	16.5%	7	7
		BG18	61%	0.032	VH4-4	VL3-25	21	11	21.5%	17.6%	11	5
		PGDM12	54%	0.140	VH3-11	VK2-24	19	9	19.1%	14.3%	7	8
		DH270.6	51%	0.210	VH1-2	VL2-23	18	10	12.8%	6.7%	5	4
V2 Apex		PG9	87%	0.154	VH3-33	VL2-14	28	10	12.6%	6.3%	9	4
		PGDM1400	83%	0.020	VH1-8	VK2-28	32	9	26.4%	11.8%	8	5
		VRC26.25	70%	0.004	VH3-30	VL1-51	36	12	12.2%	8.6%	6	1
		CH01	54%	1.379	VH3-20	VK3-20	24	9	16.7%	11.2%	11	5
MPER		10E8	98%	0.356	VH3-15	VL3-19	20	12	21.4%	13.4%	9	5
		DH511.2	98%	0.943	VH3-15	VK1-39	21	11	19.8%	14.0%	11	8
		4E10	98%	1.811	VH1-69	VK3-20	18	9	6.9%	4.1%	5	5
		VRC42.1	96%	4.090	VH1-69	VK3-20	15	9	`10.8%	5.6%	3	2
		VRC43.1	63%	1.340	VH4-4	VL7-43	19	9	11.1%	8.5%	5	2
		PGZL1	84%	6.06	VH1-69	VK3-20	15	9	20.9%	11.8%	4	3
		2F5	58%	2.832	VH2-5	VK1-13	22	9	13.1%	11.0%	7	2
Fusion Peptide		PGT151	73%	0.040	VH3-30	VK2D-29	26	9	20.8%	11.5%	11	5
Silent Face		SF12	62%	0.200	VH4-59	VK3-20	21	6	16.3%	13.9%	6	11

Only bnAbs that reached >50% neutralization breadth on a large (>50 virus) multiclade virus panel and had publicly available heavy and light chain sequences are listed in this table

^aNeutralization breadth as measured on a large multi-clade panel of HIV pseudoviruses

^bGeometric mean IC50 (ug/ml)